The Mesovouno massacre () refers to two massacres perpetrated by members of the Wehrmacht in the village of Mesovouno in Ptolemaida, Greece, during the Axis occupation of Greece, carried out on 23 October 1941 and 22 April 1944. On 23 October 1941, the Wehrmacht soldiers gathered all men aged 16–69 years old, killed them with machine guns and set the houses on fire. In 1944 the village was razed by Nazi troops two days before the massacre of the village Pyrgoi in Ptolemaida. A total of 268 civilians were killed.