Mrs. Brindle first appears in Big Nate – In the Zone and has not of yet appeared in any of the comics. In Big Nate – In the Zone Nate and Chad have to take a broken beanbag to her so she can teach them how to fix it after Nate put a hole it while playing beanbag Olympics in the library. While their they find out from her that the school is becoming a Fitness Zone, which Nate’s band get to sing about later in the book. She also once got food poisoning when showing students how to make Crab Rangoon.