Sean Penn is a weatherman in "The King Is Dead" when he has an outburst and attacks the cameraman. Neil Goldman and Chris trick Sean Penn into dressing up just like his dad, Mort, in "Once Bitten". Penn parachutes in to save Stewie after he falls from a bridge in "Hot Shots". He also brings a new supply of vaccines when they are destroyed by Peter during his and Lois' involvement with the anti-vaxxer movement. Penn is voiced by Seth Green in "The King Is Dead". He appears as himself in "Hot Shots". Sean's son Hopper also has a voice role in "Hot Shots".