The Santa Marta porcupine (Coendou sanctamartae) is a species of New World porcupine in the family Erethizontidae. It is known from dry forests on the lower slopes of the Sierra Nevada de Santa Marta and Serranía del Perijá mountains of northern Colombia, at altitudes below 500 and 1100 m, respectively, and intervening lowlands, and may also be present in nearby parts of Venezuela. It has sometimes been described as a subspecies of Coendou prehensilis. Its karyotype has 2n = 74, FN = 82.