An Item Skill is a type of skill a character has in Hyperdimension Neptunia. It allows a character to synthesize and use items in the heat of battle without having to waste a character's turn. The usage of an Item Skill is determined by several factors: the quantity of Item Synthesis Materials: (Tuffmil, Reflex, Gelatin, and Detoxin) currently in possession, the activation percentage, and various battle conditions. Item Skills can range from healing to removing status ailments.