The Nesser Brothers were a group of football playing brothers who helped make up the most famous football family in the United States from 1907 until the mid-1920s. The group consisted of seven brothers who worked for Panhandle Division of the Pennsylvania Railroad in Columbus, Ohio and who were later used as the foundation for the Columbus Panhandles of the "Ohio League", and later the National Football League, when the club was founded by future NFL-President Joe Carr in 1907.