A meteorite crashes near the town of Arborville, California. An elderly transient discovers, within the sphere, a jelly-like substance (the Blob) that attaches itself to his hand. Three high school students, Brian (Kevin Dillon), Meg (Shawnee Smith), and Paul (Donovan Leitch), encounter the man and take him to a hospital. After Brian leaves, Paul witnesses the lower half of the transient melting from exposure to the Blob. As he calls for help, the Blob drops on top of him. Meg arrives to see Paul being devoured by the growing Blob and while trying to free him his arm is torn from his body, Meg is thrown against a wall and knocked unconscious and the Blob oozes out of the hospital.