USS Lady Anne (SP-154) was an armed yacht that served in the United States Navy as a patrol vessel from 1917 to 1919. Lady Anne was built as a civilian motor yacht in 1914 by Brown at Tottenville, Staten Island, New York. On 10 April 1917, the U.S. Navy purchased her from her owner, George P. Walker of Savannah, Georgia, for use as a patrol vessel during World War I. She was enrolled in the Naval Coast Defense Reserve on 19 April 1917 and commissioned on 7 May 1917 at Charleston, South Carolina, as USS Lady Anne (SP-154) with Lieutenant, junior grade, John S. Thompson, USNRF, in command.