USS Charles F. Hughes (DD-428) was a Benson-class destroyer in the United States Navy during World War II. She was named for Charles Frederick Hughes. Charles F. Hughes was launched 16 May 1940 by Puget Sound Navy Yard, Bremerton, Washington; sponsored by Mrs. C. F. Hughes; and commissioned 5 September 1940, Lieutenant Commander G. L. Menocal in command.