As we've seen earlier, orange sidechains are hydrophobic . They want to be buried inside the protein. Blue sidechains are hydrophilic. The longest hydrophilics need plenty of space, and should point outward. Smaller hydrophilics can be on the inside of a protein without causing problems. To fix this puzzle, rotate the orange sidechain to the right. Pull the blue sidechain so it points outward. That's it, no wiggling or shaking needed once you get rid of the exposed and the clash.