The SNL Digital Short was directed by Akiva Schaffer, who also produced it along with Andy Samberg and Jorma Taccone. The title and lyrics of the song reference the popular motto and internet meme "YOLO" ("You Only Live Once"). The song parodies the phrase, and once again reworks the phrase to mean something else. The song's lyrics interpret "You Only Live Once" to mean the complete opposite of dangerous and careless behavior, and to instead be over secure and protective of life, in a negative viewpoint. The song urges people to be fully aware of their surroundings and the hazards of daily life.