USS Humphreys (DD-236/APD-12) was a Clemson-class destroyer in the United States Navy during World War II. She was named for Joshua Humphreys, a pioneer US shipbuilder. Humphreys was launched 28 July 1919 by New York Shipbuilding Corporation; sponsored by Miss Letitia A. Humphreys, great-granddaughter of Joshua Humphreys; and commissioned at Philadelphia, Pennsylvania 21 July 1920, Commander W. Baggaley in command.