Orochimaru and Ryun commonly use cursed seals on their most powerful followers. To apply a cursed seal, they needs to actually bite their intended target. Because they has sharp fangs and an extendable neck, this is a relatively simple task. The seal then appears somewhere on the target's body, and they subsequently lose consciousness. Sometime later, should they survive, they will awaken with the first level of the seal active and be enraged due to the seal's influence. The seals works by forcibly drawing chakra from the user's body, giving the user a chakra capacity beyond what they would normally be capable of, as well as increased physical performance as a result of the increased chakra capacity.