The film marks the third consecutive collaboration between Cronenberg and Viggo Mortensen (after A History of Violence and Eastern Promises). This is also the third Cronenberg film made with British film producer Jeremy Thomas, after completing together the William Burroughs adaptation Naked Lunch and the J. G. Ballard adaptation Crash. A Dangerous Method was a German/Canadian co-production. The film premiered at the 68th Venice Film Festival and was also featured at the 2011 Toronto International Film Festival.