On 17 December 1799, Enterprise departed the Delaware Capes for the Caribbean to protect United States merchantmen from the depredations of French privateers during the Quasi-War with France. Within the following year, Enterprise captured eight privateers and liberated 11 American vessels from captivity, achievements which assured her inclusion in the 14 ships retained in the Navy after the Quasi-War. Placing her for sale was suggested in mid-March 1801.