Wayne Anthony Smith (born November 17, 1979, in Etobicoke, Ontario) is a professional Canadian football offensive lineman for the Toronto Argonauts of the Canadian Football League. He was drafted first overall by the Hamilton Tiger-Cats in the 2004 CFL Draft and spent four seasons over two stints with the team. Smith won a Grey Cup championship with the Saskatchewan Roughriders in 2007. He has also been a member of the Washington Redskins and Denver Broncos of the National Football League. He played college football at Appalachian State.