The Las Plagas Undead first appeared in the movie Resident Evil: Retribution. They were unleashed by the Red Queen to fight against Leon Kennedy, Barry Burton, Luther West, Sergei Vladimir and Tony when they infiltrated Umbrella Prime to rescue Alice. They easily overpower the team with machine guns and sheer numbers and kill Tony before the group can escape. When Alice shows up in a Rolls Royce to rescue the team, the Undead continue to chase them in vehicles, but she eventually manages to evade them after killing several.