The monastery was established in 1357 by Metropolitan Alexis as a way of giving thanks for his survival in a storm. Its first hegumen was Saint Andronik, one of Sergii Radonezhsky's disciples. The extant four-pillared Saviour Cathedral was constructed from 1420–1427. The great medieval painter Andrei Rublev spent the last years of his life at the monastery and was buried there. In addition, one of the largest mass graves for lay brothers (called скудельница, skudelnitsa) was located on the cloister's premises.