Departing New York at the end of March 1842 on a trial run to Washington, D.C. with sister ship Mississippi, Missouri grounded opposite Port Tobacco, Maryland, 1 April, and did not arrive in Washington until the 13th. The warship made numerous trial runs out of the nation's capital during the spring and summer of 1842, demonstrating the advantages of steam propulsion in restricted waters to the Government, and then departed for a long cruise to the Gulf of Mexico. The frigate returned to Washington 25 April 1843 and then underwent overhaul in preparation for extended distant service.