Septimius Antiochus (died after 273) was a Roman usurper in Syria during the 3rd century. In 272 AD Emperor Aurelian had defeated the breakaway Kingdom of Palmyra: Vaballathus and his mother Zenobia were under Roman captivity. In 273 AD another rebellion against Roman rule broke out in Palmyra. The rebels first approached Aurelian's governor Marcellianus to become emperor, but he pretended to consider the offer as he sent a letter to Aurelian warning of the rebellion. While the rebels were waiting they decided to elevate Septimius Antiochus, the reputed son of Zenobia, to the purple. Receiving Marcellinus's letter, the Emperor reacted quickly, and in the spring of 273 the city was brought back under Roman rule. Aurelian punished the city heavily, but allegedly spared Antiochus.