In 1924, Mehre came to the University of Georgia as an assistant coach under George Woodruff. Upon Woodruff's retirement, Mehre became head coach and compiled a 59–34–6 record over ten years. He also was Georgia's athletic director. After leaving Georgia, Mehre served as the head coach at the University of Mississippi from 1938 to 1945, compiling a 39–26–1 record there.