Dr. Jacques van Mewtwo is the main antagonist in the RenarioExtreme series. He is Renan's arch-nemesis, who always plans to take over and rule the PokéMutant World, but is always outsmarted by Renan or his friends, and made his boss, the Shadow Lord very frustrated with him. He is often referred as "Sir" or "Master" by his servants or any Pokémon brainwashed by him. Even though he was thought to be a shameful legendary Pokémon in the series, but later in the series, it is revealed that he is actually a human, a 50-year-old man, who takes control of the body of a used Mewtwo.