USS Express No. 4 (SP-745), sometimes written as Express # 4, was a United States Navy patrol vessel in commission from 1917 to 1919. Express No. 4 was built as a private motorboat of the same name in 1917 by C. F. Ferguson at Groton, Connecticut. Upon her completion in early July 1917, the U.S. Navy leased her from her owner, M. F. Plant of Groton, for use as a section patrol boat during World War I. She was enrolled in the Naval Coast Defense Reserve and was commissioned on 2 July 1917 as USS Express No. 4 (SP-745) with Boatswain's Mate H. C. Wilson, USNRF, in command.