John Nesser (April 25, 1876 - July 29, 1931) was a professional American football player in the "Ohio League" and the early National Football League for the Columbus Panhandles. He was also a member of the Nesser Brothers, a group consisting of seven brothers who made-up the most famous football family in the United States from 1907 until the mid-1920s. After the 1921 season at age 46, John held the record as the NFL's oldest player until it was later broken by George Blanda.