Work on the aircraft began in the 1950s and was for the moment parallel to the development of the La-200B. It was planned to develop the La-250 as a heavy armed, supersonic, long range, all-weather interceptor aircraft, being equipped solely with air-to-air missiles. The La-250 received its nickname "Anakonda" during testing, the reasons for it were the stretched fuselage and the flight characteristics of the aircraft. Because the Yak-28P and the Tu-128 were more advanced aircraft, the project La-250 was cancelled in the end.