The episode opens on a conversation between Henchman 21 and his friend, Henchman 24. The nature of their conversation reveals that Henchman 24 is a ghost, but whether or not he is "real" or a product of 21's imagination is not made clear. Their conversation is interrupted by The Monarch, who enters 21's room and demands that he suit up for a mission. The show's usual title sequence is replaced by a S.P.H.I.N.X.-themed sequence. At S.P.H.I.N.X. headquarters, Colonel Hunter Gathers, the apparent leader of S.P.H.I.N.X., receives information about Monstroso's plan to take over the Venture Compound.