Sean Bubin (born January 26, 1981 in Houston, Texas) is a former American football offensive lineman of the National Football League. Originally a fifth-round pick out of the University of Illinois in 2004 by the Jacksonville Jaguars, Bubin spent time with the Jaguars, Detroit Lions, and Minnesota Vikings. He has also played for the Hamburg Sea Devils of NFL Europe. Bubin retired on April 20, 2007 after spending half the previous season on the practice squad of the New England Patriots.