Deep within the bowels of a mysterious and macabre place, not far removed from hell, something has gone horribly awry and in the mounting chaos the most unlikely of friendships will be formed, as the deadly trio collectively known as The Damned, fight to survive the facility and all of its nightmarish obstacles, while elsewhere in this very same facility there is a man sentenced to a fate worse then death, who struggles to keep his sanity intact, as the very fabric of reality is warped around him. Meanwhile Dr. Skiner, the master and founder of this facility diligently struggles to find a way to contain the escaping terrors while following all that transpires from the solitary of his private terminal.