She was born at Saumur and was raised there. Her father, Tanneguy Le Fèvre, died in 1672 and she moved to Paris, carrying with her part of an edition of Callimachus, which she afterwards published. This was so well received that she was engaged as one of the editors of the Delphin series of classical authors, in which she edited Publius Annius Florus, Dictys Cretensis, Sextus Aurelius Victor and Eutropius. Through her father she met her husband André Dacier, who was his pupil.