Apathy Syndrome is a mysterious condition that affects students of Gekkoukan High School and other residents of Tatsumi Port Island during the course of Persona 3. Those suffering from the syndrome suffer from debilitating levels of apathy. When it strikes the inflicted will collapse in a heap where ever they happen to be and become unable to move, feed, or care for themselves. The number of cases grows in correlation with the approach of the full moon, when a shadow makes an appearance somewhere in the city. The cases quickly decrease each time a Shadow is defeated, only to slowly rise again as the next full moon approaches. People affected by the Apathy Syndrome are called the Lost by the inhabitants of Tatsumi Port Island.