Two of his famous uncles were Captain William Clark and General George Rogers Clark because his mother, Lucy Clark, was their sister. His father was William Croghan of Dublin, Ireland and served in the revolutionary war at the battles of Brandywine and Monmouth. His wife Serena Livingston was the granddaughter of Robert Livingston (1718-1775) of Clermont Manor New York. Croghan died in the cholera epidemic of 1849, which also took the life of former President of the United States James K. Polk. Colonel Croghan is buried at the site of Fort Stephenson, now Fremont, Ohio.