USS Twiggs (DD-591), a Fletcher-class destroyer, was the second ship of the United States Navy to be named for Marine Major Levi Twiggs (1793–1847). Twiggs was laid down on 20 January 1943 at the Charleston Navy Yard; launched on 7 April 1943; sponsored by Mrs. Roland S. Morris; and commissioned on 4 November 1943, Commander John B. Fellows, Jr., in command.