Warren graduated from Harvard in 1745, and in 1754 married his second cousin Mercy Otis Warren, a historian and playwright. He was a descendant of Mayflower passengers Richard Warren and Edward Doty; his wife Mercy was also descended from Edward Doty. He and Mercy had five sons. During the time of the Revolution, she hosted political meetings in her home, and in 1772, she published her play, The Adulateur. After the war, in 1790, Mrs. Warren published a volume of poetry in her name. In 1805, she wrote History of the American Revolution. She died in Plymouth in 1814.