Asomatianos Tzamplakon (, ) was a Byzantine aristocrat and admiral during the Byzantine–Genoese War of 1348–1349. The Tzamplakones were an important and wealthy aristocratic family attested since the mid-13th century, when one of its members achieved the high military rank of Domestic of the Schools. Alexios Tzamplakon, Asomatianos' father, was this man's son. His brothers, Demetrios and Arsenios, also achieved high offices during the same period.