Oh No was born in a musical family. His uncle Jon Faddis is a jazz trumpeter, while his father Otis Jackson, is a singer and his brother Madlib, is a rapper. Oh No is a frequent video game player; he also has a history of remixing songs from video game soundtracks, especially from the game Blazblue. He released an album made entirely of Ethiopian Samples. In 2013, he was chosen by Rockstar Games to compose and produce the song Welcome to Los Santos, and the original score from Grand Theft Auto V, instead of Michael Hunter, who did the previous games' soundtrack.