Guerro's Explosives are powerful enough to blow up one single location. The charges are used in cutscenes in Chapter 18: "Spilling Blood for Me" and Chapter 32: "There's No Turning Back. In Chapter 29: "Doorway of The Gods", Guerro's Men set up the explosives in the doorway of the gods. The explosives blew up the chamber of the seven fathers and Quivira.