One of the most important and mysterious side characters, Spencer is the owner and founder of the Umbrella Corporation, a pharmaceutical company that secretly manufactures bio-organic weapons. His colleagues, James Marcus and Edward Ashford, join his company, but show more interest in studying the newly discovered Progenitor virus. Eventually, Ashford dies, and Spencer seizes control of the company and its research by sending his subordinates, Albert Wesker and William Birkin, to assassinate Marcus.