Alcmene's mother was the mother-in-law of Amphitryon (and later Jason), the maternal grandmother of Iphicles and Hercules and the grandmother-in-law to Deianeira and Rena. She was also the maternal-maternal great-grandmother of Hercules and Deianeira's children Klonus, Aeson and Ilea, as well as the child of Iphicles and Rena. She died of "a weak heart," a genetic condition her daughter would suffer from years later. (HTLJ: "Twilight"): Jason's statement of this to Hercules implies that she died before Hercules was born.