The Siege of Perpignan took place in 1542, at Perpignan (Spanish: Perpiñán), between a larger French army commanded by Henry, Dauphin of France and the Spanish garrison at Perpignan. The Spaniards resisted until the arrival of the Spanish army under Don Fernando Álvarez de Toledo, Duke of Alba, causing the withdrawal of the French army. The siege was one of the costliest defeats of Francis I in the French offensive of 1542.