The Battle of Serravalle took place on June 2–4, 1544, at Serravalle, in the Apennine Mountains, San Marino, between the Spanish-Imperial army commanded by Don Alfonso d'Avalos, Marquis del Vasto, and a force of freshly raised Italian mercenaries in French service, led by Pietro Strozzi, member of the rich and famous Florentine family of the Strozzi, and Giovan Francesco Orsini, Count of Pitigliano, during the Italian War of 1542–1546.