Mancuso agreed to assist the Doctor in his plan to defeat the Institute by helping to rescue Justine from the Institute and taking her to their site in the Catskill Mountains. During the confrontation there, Mancuso was shot by Stephanie, forcing the Doctor to place her on life support. When the medical computer gave her no chance of recovery, he connected McIlveen's chip to the computer so he could watch over her. (PROSE: Cat's Cradle: Warhead)
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