It has been observed a number of times that there is some link between an infection and mutation from a Progenitor virus variant and the mindset of that person. Former-Umbrella virologist Albert Wesker had long believed that the mutations inflicted on those who did not transform into zombies was simply random. However, it was his encounter with Colonel Sergei Vladimir in the Caucasus Laboratory, combined with learning scant details about James Marcus's transformation into the Queen Leech at the Umbrella Executive Training Center that changed his views.
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