About: HIV-1 Integrase   Sponge Permalink

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Integrase cleaves the DNA in such a jagged way 2 nucleotide overhangs are left. The enzyme also leaves sticky ends to the DNA to help it integrate easier into the genome of the host cell. Integrase then takes the genetic material of HIV into the nucleus, and also cleaves the host DNA with 2 nucleotide overhangs as well to integrate the DNA. The HIV genome is still attached to the DNA of the host cell, but is still not implanted in correctly. DNA Ligase comes in to fix the DNA into the host cell genome. The proviral DNA is now ready to undergo transcription and serve as a template for a viral mRNA.

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  • HIV-1 Integrase
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  • Integrase cleaves the DNA in such a jagged way 2 nucleotide overhangs are left. The enzyme also leaves sticky ends to the DNA to help it integrate easier into the genome of the host cell. Integrase then takes the genetic material of HIV into the nucleus, and also cleaves the host DNA with 2 nucleotide overhangs as well to integrate the DNA. The HIV genome is still attached to the DNA of the host cell, but is still not implanted in correctly. DNA Ligase comes in to fix the DNA into the host cell genome. The proviral DNA is now ready to undergo transcription and serve as a template for a viral mRNA.
dcterms:subject
abstract
  • Integrase cleaves the DNA in such a jagged way 2 nucleotide overhangs are left. The enzyme also leaves sticky ends to the DNA to help it integrate easier into the genome of the host cell. Integrase then takes the genetic material of HIV into the nucleus, and also cleaves the host DNA with 2 nucleotide overhangs as well to integrate the DNA. The HIV genome is still attached to the DNA of the host cell, but is still not implanted in correctly. DNA Ligase comes in to fix the DNA into the host cell genome. The proviral DNA is now ready to undergo transcription and serve as a template for a viral mRNA.
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