The Grand Arcanum is a method of Philosopher's Stone production originating from the people of Ishval that calls for at least 10,000 human souls. This method is exclusive to the 2003 anime. It was used by Scar to make a Philosopher's Stone out of Reole late in the series. It's also briefly metioned in PS2 game Curse of the Crimson Elixir as the art used to create Golems.
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