Luigi Maglione (2 March 1877—23 August 1944) was an Italian Cardinal of the Roman Catholic Church. He served as the Vatican Secretary of State under Pope Pius XII from 1939 until his death, and was elevated to the cardinalate in 1935. Pius XII never replaced Maglione as Secretary of State after his death, opting to personally assume the responsibilities of the office himself, with the assistance of two undersecretaries.