Note: This article is about the incarnation of Doctor Octopus from the 2004 movie. The mainstream version can be found here: Doctor Octopus. Evil-doer Otto Octavius, later called Doctor Octopus, is the main antagonist of the 2004 Academy Award winning Movie, Spider-Man 2. He was a scientist who became controlled by his malevolent mechanical arms, and was from there, turned into a dangerous super villain. He was portrayed by Alfred Molina who would later voice Viggo Grimborn.