Monacacy National Battlefield is located in the center of a region with a number of other Civil War battlefields and sites. It is located on Maryland State Highway 355 (Urbana Road) a few miles southeast of the city of Frederick. Nearby Interstate 70 leads westward to Antietam National Battlefield and U.S. Route 15 leads northward to the Gettysburg Battlefield. To the south on U.S. 15 is the battlefield of Balls Bluff. Monacacy National Battlefield is west of Baltimore and northwest of Washington D.C..