In the Beast Mastery system, you can unlock mutations through: Having a specific type of DNA type, Having the right colored enzymes in the right slots, and Having Real-Life luck (The stat is useless). Here's an example (A fanged Tiglon, the most common mutation): DNA Template: Sand Panther (Includes Sludge Panthers and Razorcats) Isomerase Enzyme Color in Slot #1: Green Lyase Enzyme Color in Slot #2: Green Isomerase Enzyme Color in Slot #3: Green Hydrolase Enzyme: Colorless, so any Hydrolase Enzyme will work, but high mutagen potential will increase chance of a mutation.