Serena Celia Humphrey (née van der Woodsen) is a main character in the Gossip Girl series of novels and its television adaption, in which she is portrayed by Blake Lively. Throughout the series, Serena has an on-again, off-again relationship with Dan Humphrey, the two have the longest running relationship on the show. Dan and Serena finally get married in the series finale. Serena is regarded as the "it" girl of the Upper East Side, she is best friends with Blair Waldorf and also has a close friendship withNate Archibald and Chuck Bass. When she was gone, Blair was the "it" girl.