Constantine worked at the hospital during the Blitz. One night in January 1941, Jamie was brought to him as a patient. He tried some experimental therapy with the "empty" child in Room 802 and recorded it — his empathy likely due to losing his children and grandchildren to the war. Over time, every other person in the hospital was infected; first doctors and nurses, then patients. Constantine continued to care for them and keep them comfortable, but feared the Army would bomb the place and blame it on the Germans, as other cases were appearing all over London.